Mission San Xavier del Bac
Ten miles south of downtown, this brilliant white 18th-century Spanish mission, the "White Dove of the Desert", rises out of the Santa Cruz valley, still an active parish on the Tohono O'odham Nation. The interior murals and ongoing restoration work are remarkable. Go in the morning; on weekends, Native food vendors outside sell fry bread and burros that make a perfect early lunch.
Mt. Lemmon Scenic Byway
In about an hour, the Catalina Highway climbs from saguaros at the base to pine forest and the little town of Summerhaven at 8,000+ feet, every 1,000 feet of elevation roughly equals driving 300 miles north in climate terms. It's Tucson's summer escape and a top scenic drive any season, with the Mt. Lemmon Ski Valley sky ride at the top.
Eat like it matters (it does here)
Tucson was the first US city named a UNESCO City of Gastronomy, and the title is earned daily. The mandatory list: a Sonoran hot dog (bacon-wrapped, piled high, El Güero Canelo is the famous name), a chimichanga or carne asada at a family-run Mexican institution, and dinner in the downtown/4th Avenue corridor where the city's food scene concentrates. The barrio bakeries and tortillerias aren't attractions on the way to the trip, for many visitors they become the trip.
[AFFILIATE: Tucson food tours] · [AFFILIATE: hotels in downtown Tucson]